Professor Stephen Langley

Professor Langley was appointed Consultant Urological Surgeon at the Royal Surrey County Hospital, Guildford in 1997 aged 32. He has developed an international reputation in prostate brachytherapy having successfully treated over 1,400 patients. Collaborating with the University of Surrey he has built, and leads, an award-winning research team working in the field of prostate cancer. He has established a number of medical courses and has taught the technique of prostate brachytherapy to over 150 consultants across Europe.

In 2004 he was appointed Visiting Professor of Urology at the Post Graduate Medical School of Surrey University. Professor Langley has published numerous clinical papers and presented the results of his research at many conferences. Due to his expertise he was invited to join the Department of Health’s Prostate Cancer Advisory Group and he is also Chairman of the Prostate Brachytherapy Advisory Group.

Click here to view a list of Professor Stephen Langley’s publications

PUBLICATIONS

Hattersley A, Langley SEM, Blackwood R.
Home intravenous diuretic therapy for patients with refractory heart failure.
Lancet 25th February 1989.

Langley SEM, Graves J, Fry CH.
Measurement of the ionic composition of urine with ion-selective electrodes.
Journal of Physiology 1991 438:75.

Langley SEM & Fry CH
Factors influencing the free Ca2+ in urine from normal subjects and patients with urinary tract stones.
Journal of Physiology 1991 446: 584.

Langley SEM & Fry CH.
A new method for measuring the calcium ion concentration directly in whole urine.
Journal of Urology 1993 149: 442.

Langley SEM & Fry CH.
The relationship between urinary Ca2+, pH and stone disease.  In Urolithiasis.
Ryall R & Marshall V. (eds)  Plenum Publishing Corp, New York. 1995

Langley SEM & Fry CH.
Differences in the free [Ca2+] in undiluted urine from stone formers and normal subjects using a new generation of ion-selective electrodes.
British Journal of Urology 1995 75(3): 288.

Langley SEM & Fry CH.
The influence of pH on urinary ionised [Ca2+] - Differences between urinary tract stone formers and normal subjects.
British Journal of Urology 1997 77(1): 12.

KTP laser bladder neck incision, BNI, with Nd:YAG ablation of the prostate reduces post-operative catheterization time.
SPIE Proceedings 1997.

Langley SEM, Gallegos CRR, Moisey, CU.
The evaluation of endoscopic Nd:YAG laser prostate ablation with or without KTP bladder neck incision by prospective randomized trial.
British Journal of Urology  1997 80 (6): 880.

Langley SEM, Laing R.
Prostate Brachytherapy has come of age: A review of the techniques and results.
British Journal of Urology International 2002. 89(2) 1-14.

Henderson A, Cahill D, Laing RW Langley SEM.
Iodine125 Prostate Brachytherapy: Selection strategies outcome from our first 100 consecutive patients.
British Journal of Urology International 2002. 90(6) 567-572.

J Shah, B Montgomery, SEM Langley, A Darzi,
Validation of a flexible cystoscopy course.
British Journal of Urology International 2002. 90(9) 833-835.

Henderson A, Laing RW, Langley SEM.
A spanner in the works; the use of a new temporary urethral stent to relieve bladder outflow obstruction following prostate brachytherapy.
Brachytherapy 1(4) (In Press).

Henderson A, Laing RW, Langley SEM.
Is Bicalutamide equivalent to goserelin for prostate volume reduction prior to prostate brachytherapy?
Clinical Oncology 2003; 15: 318-321

Henderson A, Laing RW, Langley SEM.
Intraoperative identification of pubic arch interference in prostate brachytherapy: simplifying the transrectal ultrasound technique.
Brachytherapy 2003; 2(4) 240-245

Bott S, Henderson A, Laing RW, Parkinson C, Langley SEM.
Setting up a prostate cancer database: how to get out more than you put in.
British Journal of Urology International 2003; 92(7) 665

Henderson A, Laing RW, Langley SEM.
Quality of Life following Treatment for Early Prostate Cancer : Does Brachytherapy offer a better quality of life?
European Urology 2004; 45 134-141

Langley SEM, Henderson A, Laing RW.
The SPIRIT of research: A new well funded randomised study comparing brachytherapy to radical prostatectomy is about to open in the UK
British Journal of Urology International (In Press, January 2004)

Bott S, Henderson A, McLarty E, Langley SEM.
A brachytherapy template approach to standardize saturation prostatic biopsy.
British Journal of Urology International 2004; 93(4) 662

Henderson A,  Ismail A, Cunningham M,  Aldridge S, Loverock L,  Langley SEM,  Laing RW.
Toxicity and early biochemical outcomes from 125Iodine prostate brachytherapy: a prospective study.
Clinical 2004; 16(2) 95-104

Langley SEM, Laing RW, Henderson A et al.
European Collaborative Group on Prostate Brachytherapy: Preliminary Report in 1175 Patients.
European Urology 2004; 46(5) 565-570

Langley SEM,  Laing RWL,  Henderson A,  Aaltomaa S,  Kataja V,  Palmgren J-E,  Bladou F,  Salem N,  Serment G,  Nava L,  Losa A,  Guazzoni G,  Guedea F,  Aguilo F,  Suarez JF.
European Collaborative Group on Prostate Brachytherapy: Preliminary Report in 1175 Patients
European Urology 2004; 46(5): 565-570

Sooikumaran P, Henderson A, Laing RW, Langley SEM.
Ofrece la braquiterapia major calidad de vida que otros tratamientos radicales para los pacientes con cáncer de próstata? 
Rev. Urol. 2004; 5(2): 83-89

Sooikumaran P, Henderson A, Laing RW, Langley SEM.
Quality of Life Issues with Prostate Brachytherapy
Urology News 2004; 8(5): 12-17

Henderson A, Andrich DEA, Pietrasik ME, Higgins D, Montgomery B, Langley SEM.
Outcome analysis and patient satisfaction following octant transrectal ultrasound-guided prostate biopsy: A prospective study comparing consultant urologist, specialist registrar and nurse practitioner in urology.
Prostate Cancer and Prostatic Diseases 2004; 7,122-125

Bott SRJ, Henderson A, Halls JE, Montgomery BSI, Laing RW, Langley  SEM.
Transperineal template biopsies of the prostate – the technique and results
Urology 2006: 68(5); 1037-1041

Khaksar SJ, Laing RW, Henderson A, Sooriakumaran P, Lovell D, Langley SEM
PSA relapse-free survival and toxicity following I-125 LDR Prostate Brachytherapy- the Guildford experience
British Journal of Urology International 2006: 98(4); 1210-1215

Guedea F, Aguilo F, Polo A, Langley A,  Laing R, Henderson A, Aaltomaa S, Kataja V, Palmgren J, Bladou F, Salem N, Serment G, Nava L, Losa A, Guazzoni G.
Initial biochemical outcomes following permanent interstitial brachytherapy as monotherapy in 1043 patients with clinical T1-T2 prostate cancer. 
Radiotherapy and Oncology 2006; 80: 57–61

Sooriakumaran P, Lovell D, Henderson A, Laing R, Langley SEM.
Gleason scoring varies among pathologists and this affects clinical risk in prostate cancer patients.
Clinical Oncology 2005; 17(8): 655-658

Simon R.J. Bott, Alastair Henderson, Robert W. Laing, Bruce S.I. Montgomery, Stephen E.M. Langley.
Technical considerations when obtaining and interpreting prostatic biopsies from men with a suspicion of early prostate cancer. 
British Journal of Urology International 2005: 96(4); 686-686

BOOKS

Ion Selective Electrodes in Biological Systems,
CH Fry & SEM Langley 2001
Harwood Academic Publishers

A patient's guide to prostate cancer.
Langley SEM 1999 & rewritten 2002, 2004, 2005

A patient's guide to prostate ebrachytheray.
Langley SEM et al  2005

A patient's guide to radical prostatectomy.
Langley SEM et al  2005

A patient's guide to prostate HIFU
Langley SEM et al  2005

A patient's guide to prostate cryotherapy
Langley SEM et al  2005

A patient's guide to external beam radiotherapy
Langley SEM et al  2005

A patient's guide to TURP
Langley SEM et al  2005

A patient’s guide to bladder cancer.
Langley SEM & Borwell J (In Press)

 

RECENTLY PUBLISHED ABSTRACTS

Cahill D, Henderson A, Langley SEM, Laing RW. (Presented by Cahill D)
Prostate Brachytherapy: Patient Assessment and Symptomatic Response
British Association of Urological Surgeons-Dublin 2001
Abstracted to British Journal of Urology International 2001;88 (Supplement 1): 49

Henderson A, Cahill D, Langley SEM, Laing RW.
Prostate Brachytherapy: A prospective analysis of urological symptoms.
British Cancer Research Meeting-Leeds 2001.
Abstracted to the British Journal Cancer 2001; 85(Supplement 1): 16

Henderson A, Cahill D, Laing RW, Langley SEM.
Prostate Brachytherapy; lessons from our first 100 patients.
European Association of Urologists, Annual Meeting, Birmingham 2002
Abstracted to European Urology 2002 1(Supplement 1) pp46

Henderson A, Laing RW, Langley SEM.
Toxicity following Iodine125 prostate brachytherapy: prospective prediction of symptoms using urodynamics.
European Society for Therapeutic Radiology and Oncology, Altalya Turkey, May 2002
Abstracted to Radiotherapy & Oncology 2002; 63(supplement 1): 48

Henderson A, Laing RW, Langley SEM.
Iodine125 prostate brachytherapy: selection strategies and early outcome.
British Association of Urological Surgeons-Glasgow 2002
Abstracted to British Journal of Urology International 2002;90(supplement 1):20(p118)

Henderson A, Laing RW, Langley SEM.
Cytoreduction for brachytherapy : Not all antiandrogens are equal
British Association of Urological Surgeons-Glasgow 2002
Abstracted to British Journal of Urology International 2002;90(supplement 1):68(p147)

Henderson A, Langley SEM, Laing RW.
Iodine125 Prostate Brachytherapy – Early outcome, toxicity and patient selection – a prospective study.
British Association of Surgical Oncology/ British Oncology Association-Cambridge 2002
Abstracted to Clinical Oncology 2002; 14(4);518(p47)

Henderson A, Langley SEM, Laing RW. 
Iodine 125 Prostate Brachytherapy – Early outcome, toxicity and patient selection – a prospective study.
European Society of Therapeutic Radiation and Oncology, Prague 2002
Abstracted to Radiotherapy & Oncology 2002;64(supplement 1): 972(s286) 

Henderson A, Laing RW, Langley SEM.
A prospective study of urinary symptoms following 125Iodine seed brachytherapy: is urodynamics the essential test to determine risk of postoperative catheter use?
European Association of Urologists, Annual Meeting, Madrid 2003
Abstracted to to European Urology  2003;2(1): pp134 (abstract 526)
Winner Best Poster In Session On Non-Surgical Treatment of Prostate Cancer

Henderson A, Andrich DEA, Pietrasik ME, Langley SEM
Outcome analysis of TRUS guided prostate biopsy: a prospective study comparing cancer detection between consultant urologist, specialist registrar and nurse specialist in oncology. European Association of Urologists, Annual Meeting, Madrid 2003
Abstracted to to European Urology 2003;2(1): pp109 (abstract 427)
Winner Best Poster In Session On Biopsy and Detection of Prostate Cancer

Henderson A, Langley SEM, Laing RW.
A Prospective Study of PSA Free Survival Following 125Iodine Seed Prostate Brachytherapy – The First Reported UK Data
British Association of Urological Surgeons, Manchester 2003
Abstracted to British Journal of Urology International 2003: 91(supplement 2):103 (p146)

Langley SEM, Henderson A, Laing RW. (Presented by Langley SEM)
The Cytoreductive Efficacy of Goserelin and Bicalutamide Prior to Radiotherapy
Innovators in Urology – Amsterdam 2003
Abstracted to Prostate Cancer and Prostatic Diseases 2003: 6(supplement 6) S19-28

Langley SEM, Curtis P, Smith JG
Ethical issues in cord blood banking
ISPOG Edinburgh 2004
Abstracted to J Psych Ob Gynae 2004: 25(1) 24

Smith JG, Langley SEM
Umbilical cord stem cells-clinical utility: the present and future
ISPOG Edinburgh 2004
Abstracted to J Psych Ob Gynae 2004: 25(1) 24

Smith JG, Langley SEM
Umbilical cord stem cells: biological aspects
ISPOG Edinburgh 2004
Abstracted to J Psych Ob Gynae 2004: 25(1) 23

Henderson A, Khaksar S, Sooriakumaran P, Higgins D, Persad R, Bobruk K, Wright MPJ, Langley SEM, Laing RWL.
Contemporary Radical Treatment for Prostate Cancer using Brachytherapy or Extraperitoneal Laparoscopic Radical Prostatectomy: 18 month Outcomes Including Urinary Function, Incontinence and Erectile Dysfunction.
European Society of Therapeutic Radiology and Oncology (ESTRO) 2006.  Abstracted to Radiotherapy and Oncology 2006

Henderson A, Khaksar S, Sooriakumaran P, Higgins D, Persad R, Bobruk K, Wright MPJ, Langley SEM, Laing RWL.
Long Term Health Related Quality of Life Outcomes Following Contemporary Radical Treatment for Prostate Cancer Using Brachytherapy of Extraperitoneal Laparoscopic Radical Prostatectomy Outcome Data. 
World Congress of Endourology 2006. 
Abstracted to Journal of Endourology 2006: 20 (S1); A170: MP 11-17

Henderson A, Khaksar S, Sooriakumaran P, Higgins D, Persad R, Bobruk K, Wright MPJ, Langley SEM, Laing RWL.
Long Term Erectile and Urinary Dysfunction Outcomes Following Contemporary Radical Treatment for Prostate Cancer using Brachytherapy or Extraperitoneal Laparoscopic Radical Prostatectomy; Outcome Data with 18 Month Follow-up.  
World Congress of Endourology 2006. 
Abstracted to Journal of Endourology 2006: 20 (S1); A170: MP 11-18

Sooriakumaran P, Macanas-Pirard P, Fox SB, Coley HM, Bucca G, Lovell DP, Henderson A, Smith CP, Langley SEM, Laing RW. (Presented by PS).
A blinded, randomized controlled trial of neo-adjuvant celecoxib in patients with early prostate cancer.  American Association of Clinical Oncology (ASCO) Atlanta 2006.
Journal of Clinical Oncology 2006: 24 (No 18S) 4563.  Winner of the ASCO Merit Award 2006

Henderson A, Persad R, Wright MPJ, Eden CG, Laing RWL and Langley SEM.
Urinary Function, Incontinence and Erectile Dysfunction Following Contemporary Radical Treatment for Prostate Cancer using Brachytherapy or Extraperitoneal Laparoscopic Radical Prostatectomy.  British Association of Urological Surgeons Annual Meeting 2006. 
Abstracted to British Journal of Urology International 2006:97 (S3); 83 p112.
Mentioned in ‘Best of BAUS’ 2006

Khaksar S, Henderson A, Sooriakumaran P, Lovell D, Laing RW and Langley SEM.
Are the USA prostate brachytherapy results reproducible in the UK?
British Association of Urological Surgeons Annual Meeting 2006. 
Abstracted to British Journal of Urology International 2006:97 (S3); 85 p116.

 

PRESENTATIONS & DEMONSTRATIONS

'Measurement of calcium ion concentration in urine with ion-selective electrodes.'
The Physiology Society, Glasgow. July 1990.

'The direct measurement of free urinary calcium in the investigation of urolithiasis.'
Medical Research Society, London. December 1990.

'The direct measurement of free urinary calcium in the investigations of urolithiasis.'
Guy's Urological Research Meeting, Guy's Hospital. January 1991.

Demonstration entitled 'Measurement of the ionic composition of urine with ion-selective electrodes.'
The Physiology Society, Royal Free Hospital, London. February 1991.

'Free Ca2+ - A determinant of urinary tract stone formation.'
The British Association of Urological Surgeons, Glasgow. June 1991.

'Factors influencing the free Ca2+ in urine from normal subjects and from patients with urinary tract stones.'
The Physiology Society, St Thomas' Hospital. November 1991.

'The relationship between urinary Ca2+, pH and stone disease.'
Symposium on Urolithiasis, Cairns, Australia. September 1992.

'A new method for measuring the calcium ion concentration directly in whole urine.'
The American Association of Urologists, San Antonio, USA. May 1993.
Awarded 'Best presentation in section' by AUA

'Management of acute retention: A more efficient service.'
The British Association of Urological Surgeons, Brighton. June 1995.

'Elective vs emergency surgery for patients presenting in acute urinary retention.'
Wessex Urological Group, Gosport. November 1995. Awarded 'Best presentation'

'KTP laser bladder neck incision, BNI, with Nd:YAG ablation of the prostate reduces post-operative catheterization time.'
The American Association of Urologists, Orlando, USA. May 1996.

'Bladder neck incision with KTP and Nd:YAG ablation of the prostate improves clinical outcome and reduces post-operative catheterization time.'
SPIE Meeting, San Jose, USA, February 1996

'KTP laser bladder neck incision with Nd:YAG ablation of the prostate reduces post-operative catheterization time and improves outcome.'
The American Association of Urologists, New Orleans, USA. April 1997.

'Prostate brachytherapy: Patient assessment and symptomatic response'
The British Association of Urological Surgeons, Dublin. June 2001.

'Prostate brachytherapy: A prospective analysis of urological symptoms'
The British Association of Oncologists, Leeds. June 2001

‘A spanner in the works, the use of stents after brachytherapy’
Third International Symposium on Urological Stents, Glasgow, September 2001

Henderson A, Laing RW, Langley SEM.
Antiandrogens in brachytherapy : Not all are equal
Urological Research Society, Royal College of Surgeons of England – January 2002

Henderson A, Cahill D, Laing RW, Langley SEM. (Presented by Langley SEM)
Prostate Brachytherapy; lessons from our first 100 patients.
Innovations in Urology,  Miami 2002

Henderson A, Laing RW, Langley SEM.
Quality of life following treatment for early prostate cancer
Brachytherapy Advanced User’s Group-York 2002

Henderson A, Laing RW, Langley SEM.
Early Outcome from Iodine125 prostate brachyterapy: The Guildford experience
British Prostate Group Spring Meeting-Queens College Cambridge 2002

Henderson A, Laing RW, Langley SEM.
Iodine125 prostate brachytherapy: selection strategies and early clinical and biochemical  outcomes, a prospective study
South Thames Regional Urology Meeting – Winning Derek Packham Medal and Prize

Henderson A, Andrich DEA, Pietrasik ME, Langley SEM
A prospective comparison of cancer detection using TRUS guided prostate biopsy between consultant urologist, specialist registrar and nurse specialist in oncology.
South West Thames Regional Urology Tumor Group Meeting, Royal Marsden Hospital.

Henderson A, Laing RW, Langley SEM.
Brachytherapy Results and case selection: Update
South West Thames Regional Urology Tumor Group Meeting, Royal Marsden Hospital.

Henderson A, Sooriakumaran P, Laing R.W. Langley S.E.M
A prospective study of PSA free survival following 125Iodine seed prostate brachytherapy- UK data with up to 55 months follow up, South West Thames Regional Urology Tumour Group Meeting Guys Hospital. 2003.

Bott S, Henderson A, Sooriakumaran P, Kooiman G, Langley SEM
Systematic saturation Prostatic biopsy using a brachytherapy template – The technique and results.. South West Thames Regional Urology Tumour Group Meeting Guys Hospital 2003.- awarded prize for best paper

Henderson A, Andrich DE*, PietrasikME, Sooikumaran P, Higgins D, Montgomery BS & Langley SEM
A prospective comparison of cancer detection using TRUS guided prostate biopsy between consultant urologist, specialist registrar and nurse specialist in oncology. *. South West Thames Regional Urology Tumour Group Meeting Guys Hospital.2003

Henderson A, Sooriakumaran P, Khaksar S, Eden C, Langley, Laing R.
European Association of Urology Annual Meeting, Paris 2006.
Long term health related quality of life after state of the art radical treatment for early prostate cancer: brachytherapy and laparoscopic radical prostatectomy outcome data with 18 month follow-up.  Abstracted to European Urology 2006

Khaksar S, Sooriakumaran P, Henderson A, Langley SEM, Laing RW.
Can US prostate brachytherapy results be reproduced in Europe?
American Society of Therapeutic & Radiation Oncology (ASTRO) Denver 2005
Abstracted to International Journal of Radiation Oncology Biology & Physics 2005: 63 (Supplement 1); S328

Henderson A, Khaksar S, Sooriakumaran P, Langley SEM, Laing RW.
Quality of life following prostate brachytherapy- HRQoL returns to baseline         after nine months
American Society of Therapeutic & Radiation Oncology (ASTRO) Denver 2005
Abstracted to International Journal of Radiation Oncology Biology & Physics 2005: 63 (Supplement 1); S333-334

Henderson A, Sooriakumaran P, Khaksar S, Laing RW, Langley SEML.
Quality of Life and Erectile Dysfunction up to 24 months after Prostate Brachytherapy – A Longitudinal Prospective Study.  British Association of Urological Surgeons Glasgow 2005
Abstracted to British Journal of Urology International 2005:95 (S5); 91 p125

Henderson A, Sooriakumaran P, Laing RW, Langley SEML. (Presented by PS)
Health related Quality of Life Following Brachytherapy – How long does recovery take?
American Urological Association Annual Meeting, San Antonio 2005
Abstracted to Journal of Urology 2005:173(4);56 (205)

Sooriakumaran P, Khaksar S, Henderson A, Laing RW, Langley SEM. (Presented by PS)
Can Europe reproduce the brachytherapy results of the USA?
European Association of Urology (EAU).  Istanbul 2005
Abstracted to European Urology 2005: 4 (3); 44 (168)

Sooriakumaran P, Henderson A, Khaksar S, Langley SEM, Laing RW. (Presented by PS)
Effects of brachytherapy on erectile function- prospective UK data.
European Association of Urology (EAU).Istanbul 2005
Abstracted to European Urology 2005: 4 (3); 82 (318)

Khaksar SJ, Sooriakumaran P, Henderson A, Langley SEM, Laing RW (Presented by SJK)
PSA Relapse Free Survival Following Prostate Brachytherapy In Intermediate and High Risk Disease.  European Society of Therapeutic Radiation and Oncology, Budapest 2005
Abstracted to Radiotherapy And Oncology 2005: 75(S1); S85